Mechanism of action

The active substance of Buy Cialis Tadalafil is Tadalafil 10mg Dosage, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil Tablets Usp 20 Mg.

Rules of admission

The duration of the generic Cialis Tadalafil Tablets reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil Generic Cialis 20mg should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

To sum up: buy Tadalafil Tablets India (Tadalafil Generic Cialis 20mg) should be because

• it has a duration of 36 hours.
• virtually no side effects
• effective in diabetics
• can be combined with meals and strong drinks
• not addictive
• helps to get rid of worries about possible failure

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Effect of other drugs on Cialis Tadalafil 20 Mg Tablets

Cialis Tadalafil Tablets is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Tadalafil Dosage For Erectile Dysfunction in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Tadalafil 10mg Dosage in a single dose by 107% and Smachna 15% relative to the AUC values for Tadalafil Eli Lilly Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Tadalafil Dosage For Erectile Dysfunction in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Tadalafil 5mg India activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Tadalafil 5mg India (AUC) by 88% and SMACNA 46% relative to the AUC values for Tadalafil Citrate Dosage Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Tadalafil 10mg Tablets in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Tadalafil Cialis From India reduces the rate of absorption of Tadalafil Eli Lilly without changing the area under the pharmacokinetic curve for Tadalafil Cialis 20mg. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Tadalafil Tablets.

The safety and effectiveness of the combination of Tadalafil Tablets India with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Tadalafil 20 Mg Tablets does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Recommendations and contraindications

Be sure to consult your doctor before taking Tadalafil For Erectile Dysfunction pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

• Like any other drug of this action, Cialis Tadalafil Buy Online is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
• The body, which is sensitive to any of the components of Tadalafil Cialis From India, Tadalafil Tablets India is strictly contraindicated.
• It should not be used by persons under the age of 18.
• Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Tadalafil 5mg India.

Side effects and overdose

Due to the well-studied experience of Tadalafil Dosage For Erectile Dysfunction, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

• Mild headaches
• Dizziness and vomiting
• A rush of blood to the face
• Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Clinical pharmacology

Tadalafil Cialis 20mg is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Tadalafil 10mg Dosage leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil For Erectile Dysfunction has no effect in the absence of sexual arousal.

In vitro studies have shown that Tadalafil Citrate Dosage is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Tadalafil Eli Lilly on PDE-5 is more active than on other PDES. Cialis Tadalafil 10mg Tablets is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Tadalafil Canada is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Tadalafil Tablets India is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Tadalafil 5mg India is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Tadalafil Tablets India improves erection and increases the possibility of a full sexual intercourse.

Tadalafil Dosage For Erectile Dysfunction in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Tadalafil 20 Mg Tablets does not cause a significant change in heart rate.

Buy Cialis Tadalafil does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Tadalafil Citrate Dosage on visual acuity, electroretinogram, intraocular pressure and pupil size.

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