Clinical pharmacology
Tadalafil Citrate Dosage is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Tadalafil Citrate Dosage leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil Cialis 20mg has no effect in the absence of sexual arousal.
In vitro studies have shown that Cialis Tadalafil Tablets is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Tadalafil Generic Cialis 20mg on PDE-5 is more active than on other PDES. Cialis Tadalafil 20 Mg Tablets is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Tadalafil For Erectile Dysfunction is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Tadalafil Tablets Usp 20 Mg is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Tadalafil Tablets India is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.
Tadalafil For Erectile Dysfunction improves erection and increases the possibility of a full sexual intercourse.
Tadalafil Tablets India in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cheap Generic Tadalafil does not cause a significant change in heart rate.
Cialis Tadalafil Tablets does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Tadalafil Tablets Usp 20 Mg on visual acuity, electroretinogram, intraocular pressure and pupil size.
Mechanism of action
The active substance of Tadalafil Cialis From India is Tadalafil Eli Lilly, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.
After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.
The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil 5mg India.
Rules of admission
The duration of the generic Cheap Generic Tadalafil reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil Tablets Usp 20 Mg should be water.
Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.
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Dosage and administration
Inside. Use of Tadalafil Cialis 20mg Tadalafil Generic Cialis 20mg according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil 5mg India at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Tablets India. The maximum daily dose of Tadalafil Eli Lilly is 20 mg. the Use of Tadalafil 5mg India according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil Tablets India when used once a day is 5 mg; Tadalafil Tablets Usp 20 Mg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil Cialis 20mg is contraindicated.
Side effect
Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.
Overdose
Symptoms: with a single appointment to healthy individuals Tadalafil 40 Mg Dosage at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil Usa in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil Cialis From India practically displayed.
Interaction with other drugs
Tadalafil Eli Lilly is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil 40 Mg Dosage. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil Generic Cialis 20mg reduced the rate of absorption of the latter without changing the AUC. Cialis Tadalafil Buy Online enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tadalafil Buy Online on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Generic Cialis 20mg in patients receiving nitrates is contraindicated
Tadalafil Tablets Usp 20 Mg is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Tadalafil 40 Mg Dosage in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Tadalafil Cialis From India in a single dose by 107% and Smachna 15% relative to the AUC values for Tadalafil 5mg India Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Tadalafil Eli Lilly in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Tadalafil Usa activity.
Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Tadalafil Citrate Dosage (AUC) by 88% and SMACNA 46% relative to the AUC values for Tadalafil For Erectile Dysfunction Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Tadalafil Tablets Usp 20 Mg in plasma.
Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Tadalafil 10mg Dosage reduces the rate of absorption of Cialis Tadalafil Buy Online without changing the area under the pharmacokinetic curve for Cialis Tadalafil Tablets. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Tadalafil Dosage For Erectile Dysfunction.
The safety and effectiveness of the combination of Tadalafil Eli Lilly with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.
Cheap Generic Tadalafil does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.
Tadalafil For Erectile Dysfunction
