Dosage and administration

Inside. Use of Tadalafil Cialis From India Buy Cialis Tadalafil according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Tadalafil Buy Online at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Tablets Usp 20 Mg. The maximum daily dose of Cialis Tadalafil 20 Mg Tablets is 20 mg. the Use of Tadalafil Cialis 20mg according to the indication of BPH or ED/BPH. The recommended dose of Buy Tadalafil Canada when used once a day is 5 mg; Tadalafil Tablets India should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Tadalafil Buy Online is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Tadalafil Citrate Dosage at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil Usa in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil 40 Mg Dosage practically displayed.

Interaction with other drugs

Cialis Tadalafil Tablets is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Buy Cialis Tadalafil. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil Usa reduced the rate of absorption of the latter without changing the AUC. Cialis Tadalafil 10mg Tablets enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Cialis From India on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Citrate Dosage in patients receiving nitrates is contraindicated

Mechanism of action

The active substance of Tadalafil 10mg Dosage is Cialis Tadalafil 10mg Tablets, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil Cialis 20mg.

Rules of admission

The duration of the generic Tadalafil Eli Lilly reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Tadalafil Buy Online should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Pharmacokinetics

The pharmacokinetics of Tadalafil Cialis 20mg in patients with erectile dysfunction is similar to the pharmacokinetics of Tadalafil Citrate Dosage in persons without erectile dysfunction. Absorption After taking Tadalafil 5mg India inside Tadalafil Cialis From India is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Tadalafil Tablets Usp 20 Mg does not depend on the meal, so Tadalafil For Erectile Dysfunction can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cheap Generic Tadalafil in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Tadalafil Citrate Dosage 1 time/day. The average Vd is about 63 liters, which indicates that Tadalafil Cialis 20mg is distributed in the tissues of the body. The plasma protein binding of Tadalafil Usa at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cheap Generic Tadalafil is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Tadalafil Tablets. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Tadalafil Cialis From India when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Tadalafil For Erectile Dysfunction is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis Tadalafil 10mg Tablets when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Tadalafil Buy Online (AUC), patients with severe renal insufficiency are not recommended to use Cialis Tadalafil Tablets. The pharmacokinetics of Buy Tadalafil Canada in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Tadalafil Canada to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Tadalafil Usa. In patients with diabetes mellitus during the use of Tadalafil Tablets Usp 20 Mg AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of other drugs on Tadalafil Dosage For Erectile Dysfunction

Tadalafil Eli Lilly is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Tadalafil 40 Mg Dosage in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Tadalafil Cialis From India in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Tadalafil Tablets Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Tadalafil Usa in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cheap Generic Tadalafil activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Tadalafil 10mg Tablets (AUC) by 88% and SMACNA 46% relative to the AUC values for Tadalafil For Erectile Dysfunction Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Tadalafil Tablets Usp 20 Mg in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Tadalafil Eli Lilly reduces the rate of absorption of Cialis Tadalafil Tablets without changing the area under the pharmacokinetic curve for Tadalafil 10mg Dosage. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Buy Cialis Tadalafil.

The safety and effectiveness of the combination of Tadalafil Cialis 20mg with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Tadalafil Tablets Usp 20 Mg does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

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