Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Tadalafil Tablets on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Tadalafil Buy Online compared to placebo.

The efficacy and safety of Cialis Tadalafil Tablets (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Tadalafil Cialis 20mg 1 time per day. In studies of the primary efficacy of Tadalafil 40 Mg Dosage at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Tadalafil 5mg India at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Tadalafil Tablets India in patients with BPH — inhibition of PDE-5 Cialis Tadalafil 10mg Tablets, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Tadalafil Generic Cialis 20mg Cialis Tadalafil Tablets according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Tablets Usp 20 Mg at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil For Erectile Dysfunction. The maximum daily dose of Tadalafil Tablets India is 20 mg.

The use of Tadalafil 40 Mg Dosage Tadalafil Cialis From India for indication of BPH or ED/BPH.The recommended dose of Tadalafil Citrate Dosage when used once a day is 5 mg; Tadalafil Cialis From India should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Tadalafil Generic Cialis 20mg once a day is not recommended.

Clinical pharmacology

Tadalafil Cialis 20mg is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Tadalafil Dosage For Erectile Dysfunction leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil Citrate Dosage has no effect in the absence of sexual arousal.

In vitro studies have shown that Tadalafil Tablets India is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Tadalafil 10mg Dosage on PDE-5 is more active than on other PDES. Tadalafil Cialis 20mg is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Tadalafil 10mg Dosage is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Tadalafil Cialis 20mg is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Tadalafil Cialis 20mg is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Tadalafil 20 Mg Tablets improves erection and increases the possibility of a full sexual intercourse.

Cialis Tadalafil 20 Mg Tablets in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Tadalafil Dosage For Erectile Dysfunction does not cause a significant change in heart rate.

Tadalafil Generic Cialis 20mg does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Tadalafil 20 Mg Tablets on visual acuity, electroretinogram, intraocular pressure and pupil size.

Dosage and administration

Inside. Use of Tadalafil Dosage For Erectile Dysfunction Tadalafil 10mg Dosage according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Cialis From India at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Eli Lilly. The maximum daily dose of Cialis Tadalafil Tablets is 20 mg. the Use of Tadalafil Citrate Dosage according to the indication of BPH or ED/BPH. The recommended dose of Cheap Generic Tadalafil when used once a day is 5 mg; Tadalafil Citrate Dosage should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Tadalafil Tablets is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Tadalafil Dosage For Erectile Dysfunction at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Tadalafil 10mg Tablets in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil Dosage For Erectile Dysfunction practically displayed.

Interaction with other drugs

Tadalafil 40 Mg Dosage is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil Tablets India. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Tadalafil 10mg Tablets reduced the rate of absorption of the latter without changing the AUC. Tadalafil 40 Mg Dosage enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Cialis From India on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Generic Cialis 20mg in patients receiving nitrates is contraindicated

Peculiar properties

On sale Buy Cialis Tadalafil first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Tadalafil Generic Cialis 20mg. As a result, the sale soon appeared exact copies of Cialis Tadalafil 10mg Tablets — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Tadalafil 40 Mg Dosage, whether it will harm health — similar thoughts arise in many who want to buy Cialis Tadalafil Tablets. I must say that such doubts are in vain, as Tadalafil Dosage For Erectile Dysfunction-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Cialis Tadalafil Tablets is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Tadalafil Citrate Dosage is based on the properties of Cialis Tadalafil Tablets, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

The long-term effect of Tadalafil Citrate Dosage allows you not to worry about what you need to do everything in time: taking a pill, a man will be able to quality sexual intercourse within 1.5 days.

What else is the argument for purchasing Tadalafil Tablets India?

Many men want to buy generic Tadalafil Tablets Usp 20 Mg, not viagra, as in parallel with taking the pill you can drink alcohol and eat (even fat) without any health consequences. In addition, Cialis Tadalafil 20 Mg Tablets does not serve as a reason for excitement, but only normalizes erectile function, allowing men to lead a full sexual life.

In addition, clinical trials have shown that men who underwent therapeutic treatment with Buy Cialis Tadalafil, noticed an improvement in erection and after taking generic.

Tadalafil Tablets Usp 20 Mg