Mechanism of action

The active substance of Tadalafil Tablets India is Cialis Tadalafil 20 Mg Tablets, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil Dosage For Erectile Dysfunction.

Rules of admission

The duration of the generic Tadalafil Tablets India reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cheap Generic Tadalafil should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

To sum up: buy Tadalafil Usa (Buy Tadalafil Canada) should be because

• it has a duration of 36 hours.
• virtually no side effects
• effective in diabetics
• can be combined with meals and strong drinks
• not addictive
• helps to get rid of worries about possible failure

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Dosage and administration

Inside. Use of Tadalafil Citrate Dosage Cialis Tadalafil Buy Online according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Eli Lilly at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil 40 Mg Dosage. The maximum daily dose of Tadalafil 40 Mg Dosage is 20 mg. the Use of Tadalafil For Erectile Dysfunction according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil 10mg Dosage when used once a day is 5 mg; Tadalafil Tablets Usp 20 Mg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil Generic Cialis 20mg is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Buy Tadalafil Canada at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Tadalafil Tablets in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Tadalafil 20 Mg Tablets practically displayed.

Interaction with other drugs

Tadalafil Eli Lilly is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cheap Generic Tadalafil. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil 5mg India reduced the rate of absorption of the latter without changing the AUC. Buy Tadalafil Canada enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil 40 Mg Dosage on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Tablets India in patients receiving nitrates is contraindicated

Effect of other drugs on Buy Cialis Tadalafil

Tadalafil Citrate Dosage is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Tadalafil 20 Mg Tablets in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Tadalafil 20 Mg Tablets in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Tadalafil Tablets Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Tadalafil Usa in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Tadalafil Tablets activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Tadalafil Tablets (AUC) by 88% and SMACNA 46% relative to the AUC values for Tadalafil 40 Mg Dosage Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Tadalafil Citrate Dosage in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Tadalafil Tablets Usp 20 Mg reduces the rate of absorption of Tadalafil Tablets India without changing the area under the pharmacokinetic curve for Tadalafil Eli Lilly. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Tadalafil 5mg India.

The safety and effectiveness of the combination of Tadalafil Tablets Usp 20 Mg with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Tadalafil 10mg Dosage does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Tadalafil Dosage For Erectile Dysfunction on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Tadalafil Generic Cialis 20mg compared to placebo.

The efficacy and safety of Tadalafil Generic Cialis 20mg (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Tadalafil 5mg India 1 time per day. In studies of the primary efficacy of Tadalafil Dosage For Erectile Dysfunction at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Tadalafil Tablets at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Tadalafil Citrate Dosage in patients with BPH — inhibition of PDE-5 Tadalafil 5mg India, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Tadalafil Buy Online Cialis Tadalafil Tablets according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Eli Lilly at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil 40 Mg Dosage. The maximum daily dose of Tadalafil Dosage For Erectile Dysfunction is 20 mg.

The use of Tadalafil For Erectile Dysfunction Tadalafil Dosage For Erectile Dysfunction for indication of BPH or ED/BPH.The recommended dose of Tadalafil 10mg Dosage when used once a day is 5 mg; Tadalafil Cialis From India should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Tadalafil 5mg India once a day is not recommended.

Tadalafil 10mg Dosage