Pharmacokinetics

The pharmacokinetics of Cialis Tadalafil 20 Mg Tablets in patients with erectile dysfunction is similar to the pharmacokinetics of Cheap Generic Tadalafil in persons without erectile dysfunction. Absorption After taking Cialis Tadalafil Tablets inside Tadalafil 10mg Dosage is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Tadalafil 10mg Dosage does not depend on the meal, so Tadalafil 5mg India can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Tadalafil Cialis 20mg in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Buy Cialis Tadalafil 1 time/day. The average Vd is about 63 liters, which indicates that Cheap Generic Tadalafil is distributed in the tissues of the body. The plasma protein binding of Buy Tadalafil Canada at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Tadalafil Tablets Usp 20 Mg is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Buy Tadalafil Canada. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Tadalafil Citrate Dosage when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Tadalafil Canada is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Tadalafil Dosage For Erectile Dysfunction when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cheap Generic Tadalafil (AUC), patients with severe renal insufficiency are not recommended to use Cialis Tadalafil 10mg Tablets. The pharmacokinetics of Tadalafil 10mg Dosage in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cheap Generic Tadalafil to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cheap Generic Tadalafil. In patients with diabetes mellitus during the use of Cialis Tadalafil 20 Mg Tablets AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of Buy Tadalafil Canada on other drugs

It is known that Tadalafil 5mg India increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tadalafil Tablets on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Tadalafil Tablets in patients receiving nitrates is contraindicated.

Tadalafil Cialis From India does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Tadalafil 20 Mg Tablets does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Tadalafil Cialis From India does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Tadalafil Tablets does not affect the action of warfarin against PV.

Tadalafil Cialis From India does not increase the duration of bleeding caused by acetylsalicylic acid.

Tadalafil Cialis 20mg has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Tadalafil Usa should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Tadalafil 5mg India in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Tadalafil Citrate Dosage with doxazosin is contraindicated. When using Buy Tadalafil Canada healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Tadalafil 5mg India did not affect the concentration of alcohol, nor did alcohol affect the concentration of Tadalafil 10mg Dosage. At high doses of alcohol (0.7 g/kg), Cialis Tadalafil Buy Online did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Tadalafil 10mg Dosage in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Tadalafil 40 Mg Dosage has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Dosage and administration

Inside. Use of Tadalafil Tablets India Cialis Tadalafil 10mg Tablets according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cheap Generic Tadalafil at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil 40 Mg Dosage. The maximum daily dose of Tadalafil Cialis From India is 20 mg. the Use of Tadalafil For Erectile Dysfunction according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil 40 Mg Dosage when used once a day is 5 mg; Tadalafil 5mg India should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Tadalafil Canada is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Tadalafil For Erectile Dysfunction at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil 10mg Dosage in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil Cialis From India practically displayed.

Interaction with other drugs

Buy Cialis Tadalafil is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Tadalafil 20 Mg Tablets. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil Tablets Usp 20 Mg reduced the rate of absorption of the latter without changing the AUC. Tadalafil Cialis From India enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Usa on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Tablets Usp 20 Mg in patients receiving nitrates is contraindicated

Mechanism of action

The active substance of Cialis Tadalafil 10mg Tablets is Tadalafil 5mg India, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil 5mg India.

Rules of admission

The duration of the generic Tadalafil Eli Lilly reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil 5mg India should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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