Dosage and administration

Inside. Use of Tadalafil Eli Lilly Tadalafil Citrate Dosage according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Tadalafil Tablets at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Dosage For Erectile Dysfunction. The maximum daily dose of Tadalafil Cialis 20mg is 20 mg. the Use of Buy Cialis Tadalafil according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil Generic Cialis 20mg when used once a day is 5 mg; Buy Cialis Tadalafil should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Tadalafil Buy Online is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Tadalafil 10mg Tablets at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil Tablets Usp 20 Mg in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Tadalafil 10mg Tablets practically displayed.

Interaction with other drugs

Cialis Tadalafil 20 Mg Tablets is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil 40 Mg Dosage. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil 40 Mg Dosage reduced the rate of absorption of the latter without changing the AUC. Tadalafil Citrate Dosage enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil For Erectile Dysfunction on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Citrate Dosage in patients receiving nitrates is contraindicated

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Buy Cialis Tadalafil on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Tadalafil Tablets India compared to placebo.

The efficacy and safety of Cialis Tadalafil Tablets (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Tadalafil Tablets 1 time per day. In studies of the primary efficacy of Cheap Generic Tadalafil at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Tadalafil Cialis 20mg at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Tadalafil Cialis From India in patients with BPH — inhibition of PDE-5 Tadalafil Eli Lilly, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Tadalafil 5mg India Cheap Generic Tadalafil according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Tablets India at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Tadalafil. The maximum daily dose of Tadalafil 10mg Dosage is 20 mg.

The use of Tadalafil 5mg India Tadalafil Citrate Dosage for indication of BPH or ED/BPH.The recommended dose of Cialis Tadalafil Tablets when used once a day is 5 mg; Tadalafil 10mg Dosage should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Tadalafil Buy Online once a day is not recommended.

Effect of Buy Tadalafil Canada on other drugs

It is known that Tadalafil For Erectile Dysfunction increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cheap Generic Tadalafil on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Tadalafil Usa in patients receiving nitrates is contraindicated.

Buy Tadalafil Canada does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Tadalafil Tablets does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Tadalafil 10mg Tablets does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Tadalafil 10mg Dosage does not affect the action of warfarin against PV.

Tadalafil Usa does not increase the duration of bleeding caused by acetylsalicylic acid.

Tadalafil Usa has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Tadalafil Citrate Dosage should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Tadalafil Dosage For Erectile Dysfunction in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Tadalafil Cialis From India with doxazosin is contraindicated. When using Cialis Tadalafil 20 Mg Tablets healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Tadalafil 10mg Tablets did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Tadalafil 20 Mg Tablets. At high doses of alcohol (0.7 g/kg), Buy Tadalafil Canada did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Tadalafil 20 Mg Tablets in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Tadalafil 10mg Dosage has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Pharmacokinetics

The pharmacokinetics of Tadalafil Cialis From India in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Tadalafil Buy Online in persons without erectile dysfunction.

Suction

After taking Cialis Tadalafil 20 Mg Tablets inside Cialis Tadalafil 20 Mg Tablets is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Tadalafil 10mg Tablets does not depend on the meal, so Cialis Tadalafil Buy Online® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Tadalafil 10mg Tablets in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Tadalafil Eli Lilly 1 time/day.

The average Vd is about 63 liters, which indicates that Tadalafil Cialis 20mg is distributed in the tissues of the body.

The plasma protein binding of Tadalafil 40 Mg Dosage at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Tadalafil Tablets Usp 20 Mg is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Buy Tadalafil Canada. Therefore, the concentration of this metabolite is not clinically significant.

Breeding

In healthy individuals, the average clearance of Cialis Tadalafil 10mg Tablets when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Tadalafil Generic Cialis 20mg is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Tadalafil Citrate Dosage when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Tadalafil Cialis From India (AUC), patients with severe renal insufficiency are not recommended to use Tadalafil Dosage For Erectile Dysfunction®.

The pharmacokinetics of Buy Tadalafil Canada in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Tadalafil Dosage For Erectile Dysfunction Tadalafil Usa® patients with severe liver failure must first assess the risk and benefit of Cialis Tadalafil 10mg Tablets.

In patients with diabetes mellitus during the use of Tadalafil For Erectile Dysfunction AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Cialis Tadalafil 20 Mg Tablets