Mechanism of action

The active substance of Cialis Tadalafil 20 Mg Tablets is Tadalafil Cialis From India, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Buy Cialis Tadalafil.

Rules of admission

The duration of the generic Cialis Tadalafil 20 Mg Tablets reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Tadalafil Canada should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

To sum up: buy Tadalafil Citrate Dosage (Tadalafil Cialis From India) should be because

• it has a duration of 36 hours.
• virtually no side effects
• effective in diabetics
• can be combined with meals and strong drinks
• not addictive
• helps to get rid of worries about possible failure

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Dosage and administration

Inside. Use of Cialis Tadalafil Buy Online Tadalafil Citrate Dosage according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Usa at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Tadalafil Tablets. The maximum daily dose of Buy Tadalafil Canada is 20 mg. the Use of Tadalafil Dosage For Erectile Dysfunction according to the indication of BPH or ED/BPH. The recommended dose of Cialis Tadalafil Buy Online when used once a day is 5 mg; Tadalafil 40 Mg Dosage should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil Dosage For Erectile Dysfunction is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Tadalafil Tablets at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil 10mg Dosage in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil 40 Mg Dosage practically displayed.

Interaction with other drugs

Tadalafil 10mg Dosage is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil Tablets Usp 20 Mg. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Tadalafil 20 Mg Tablets reduced the rate of absorption of the latter without changing the AUC. Cheap Generic Tadalafil enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tadalafil Buy Online on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Tadalafil Tablets in patients receiving nitrates is contraindicated

Effect of Tadalafil Cialis 20mg on other drugs

It is known that Tadalafil 40 Mg Dosage increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil 5mg India on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Tadalafil Tablets India in patients receiving nitrates is contraindicated.

Cialis Tadalafil 10mg Tablets does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Tadalafil Generic Cialis 20mg does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Tadalafil Tablets does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Tadalafil Tablets Usp 20 Mg does not affect the action of warfarin against PV.

Tadalafil For Erectile Dysfunction does not increase the duration of bleeding caused by acetylsalicylic acid.

Tadalafil Tablets India has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Tadalafil 40 Mg Dosage should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Tadalafil Cialis From India in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Tadalafil Citrate Dosage with doxazosin is contraindicated. When using Tadalafil Cialis From India healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Tadalafil Generic Cialis 20mg did not affect the concentration of alcohol, nor did alcohol affect the concentration of Tadalafil Cialis 20mg. At high doses of alcohol (0.7 g/kg), Tadalafil Dosage For Erectile Dysfunction did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Tadalafil Citrate Dosage in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Tadalafil Tablets India has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Tadalafil 10mg Dosage on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Tadalafil Cialis 20mg compared to placebo.

The efficacy and safety of Tadalafil 10mg Dosage (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Tadalafil Cialis 20mg 1 time per day. In studies of the primary efficacy of Tadalafil Cialis 20mg at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Tadalafil 20 Mg Tablets at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Tadalafil 20 Mg Tablets in patients with BPH — inhibition of PDE-5 Tadalafil Dosage For Erectile Dysfunction, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Tadalafil Generic Cialis 20mg Cialis Tadalafil 20 Mg Tablets according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Dosage For Erectile Dysfunction at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil 10mg Dosage. The maximum daily dose of Tadalafil Cialis From India is 20 mg.

The use of Tadalafil Eli Lilly Cialis Tadalafil Tablets for indication of BPH or ED/BPH.The recommended dose of Tadalafil Citrate Dosage when used once a day is 5 mg; Cheap Generic Tadalafil should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Tadalafil Citrate Dosage once a day is not recommended.

Cialis Tadalafil Tablets