Dosage and administration

Inside. Use of Tadalafil Dosage For Erectile Dysfunction Tadalafil For Erectile Dysfunction according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Tadalafil at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Tadalafil. The maximum daily dose of Tadalafil Generic Cialis 20mg is 20 mg. the Use of Tadalafil Citrate Dosage according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil Dosage For Erectile Dysfunction when used once a day is 5 mg; Cialis Tadalafil Tablets should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Cialis Tadalafil is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cheap Generic Tadalafil at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil For Erectile Dysfunction in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Tadalafil 20 Mg Tablets practically displayed.

Interaction with other drugs

Cheap Generic Tadalafil is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil Generic Cialis 20mg. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil Cialis From India reduced the rate of absorption of the latter without changing the AUC. Tadalafil Citrate Dosage enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Cialis From India on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil Usa in patients receiving nitrates is contraindicated

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Buy Cialis Tadalafil on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Tadalafil Usa compared to placebo.

The efficacy and safety of Cialis Tadalafil Tablets (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Tadalafil Tablets Usp 20 Mg 1 time per day. In studies of the primary efficacy of Tadalafil Tablets Usp 20 Mg at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Tadalafil For Erectile Dysfunction at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Tadalafil Usa in patients with BPH — inhibition of PDE-5 Tadalafil Cialis 20mg, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Tadalafil 5mg India Tadalafil Dosage For Erectile Dysfunction according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Tablets India at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Usa. The maximum daily dose of Tadalafil 5mg India is 20 mg.

The use of Buy Tadalafil Canada Cialis Tadalafil 20 Mg Tablets for indication of BPH or ED/BPH.The recommended dose of Cialis Tadalafil 10mg Tablets when used once a day is 5 mg; Cialis Tadalafil Buy Online should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Tadalafil Tablets Usp 20 Mg once a day is not recommended.

Pharmacokinetics

The pharmacokinetics of Tadalafil Cialis 20mg in patients with erectile dysfunction is similar to the pharmacokinetics of Buy Tadalafil Canada in persons without erectile dysfunction. Absorption After taking Tadalafil Eli Lilly inside Tadalafil 10mg Dosage is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Tadalafil Eli Lilly does not depend on the meal, so Cialis Tadalafil 20 Mg Tablets can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Buy Cialis Tadalafil in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Buy Cialis Tadalafil 1 time/day. The average Vd is about 63 liters, which indicates that Tadalafil Tablets Usp 20 Mg is distributed in the tissues of the body. The plasma protein binding of Tadalafil Eli Lilly at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Tadalafil 10mg Dosage is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Tadalafil Generic Cialis 20mg. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Tadalafil Cialis 20mg when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Tadalafil 5mg India is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Tadalafil Cialis From India when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Tadalafil 10mg Tablets (AUC), patients with severe renal insufficiency are not recommended to use Cialis Tadalafil Buy Online. The pharmacokinetics of Cialis Tadalafil Tablets in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Tadalafil Canada to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Tadalafil Cialis From India. In patients with diabetes mellitus during the use of Cialis Tadalafil Tablets AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Mechanism of action

The active substance of Tadalafil Usa is Cheap Generic Tadalafil, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Tadalafil 20 Mg Tablets.

Rules of admission

The duration of the generic Tadalafil Eli Lilly reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Tadalafil Canada should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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