Mechanism of action
The active substance of Tadalafil 40 Mg Dosage is Tadalafil Tablets Usp 20 Mg, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.
After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.
The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil 10mg Dosage.
Rules of admission
The duration of the generic Tadalafil Dosage For Erectile Dysfunction reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil Generic Cialis 20mg should be water.
Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.
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- it has a duration of 36 hours.
- virtually no side effects
- effective in diabetics
- can be combined with meals and strong drinks
- not addictive
- helps to get rid of worries about possible failure
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Dosage and administration
Inside. Use of Cialis Tadalafil Tablets Tadalafil Citrate Dosage according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil 5mg India at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Tadalafil Buy Online. The maximum daily dose of Cialis Tadalafil Tablets is 20 mg. the Use of Tadalafil Eli Lilly according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil 40 Mg Dosage when used once a day is 5 mg; Tadalafil Dosage For Erectile Dysfunction should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil For Erectile Dysfunction is contraindicated.
Side effect
Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.
Overdose
Symptoms: with a single appointment to healthy individuals Tadalafil Dosage For Erectile Dysfunction at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil 10mg Dosage in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil Cialis From India practically displayed.
Interaction with other drugs
Tadalafil 5mg India is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil 10mg Dosage. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil Usa reduced the rate of absorption of the latter without changing the AUC. Tadalafil For Erectile Dysfunction enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tadalafil Buy Online on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Tadalafil Buy Online in patients receiving nitrates is contraindicated
About Cialis Tadalafil 10mg Tablets
Tadalafil Generic Cialis 20mg is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Tadalafil For Erectile Dysfunction was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!
The main feature of Tadalafil Cialis 20mg is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Tadalafil Cialis 20mg, and lead a normal life before the natural desire. In addition, the effectiveness of Tadalafil Generic Cialis 20mg will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.
Action of preparation
We all understand that the main effect of the action of Tadalafil Generic Cialis 20mg should be only one – increasing potency in men. This is exactly what happens after the use of Cialis Tadalafil 20 Mg Tablets, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Buy Tadalafil Canada.
Application and dosage
Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.
Pharmacokinetics
The pharmacokinetics of Buy Cialis Tadalafil in patients with erectile dysfunction is similar to the pharmacokinetics of Tadalafil 40 Mg Dosage in persons without erectile dysfunction.
Suction
After taking Tadalafil Dosage For Erectile Dysfunction inside Tadalafil 5mg India is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Tadalafil Generic Cialis 20mg does not depend on the meal, so Cheap Generic Tadalafil® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.
The pharmacokinetics of Buy Tadalafil Canada in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.
Distribution
Css in plasma are attained within 5 days while taking Cialis Tadalafil Tablets 1 time/day.
The average Vd is about 63 liters, which indicates that Buy Tadalafil Canada is distributed in the tissues of the body.
The plasma protein binding of Tadalafil Citrate Dosage at therapeutic concentrations 94%.
In healthy individuals, less than 0.0005% of the administered dose was found in sperm.
Metabolism
Tadalafil Tablets Usp 20 Mg is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Tadalafil Generic Cialis 20mg. Therefore, the concentration of this metabolite is not clinically significant.
Breeding
In healthy individuals, the average clearance of Cheap Generic Tadalafil when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Tadalafil Tablets is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).
Pharmacokinetics in special clinical cases
Binding to proteins does not change with impaired renal function.
Healthy elderly patients (65 years and more) had a lower clearance of Tadalafil 10mg Dosage when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.
In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Tadalafil 40 Mg Dosage (AUC), patients with severe renal insufficiency are not recommended to use Tadalafil 10mg Dosage®.
The pharmacokinetics of Tadalafil Tablets India in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Tadalafil 10mg Dosage Tadalafil Cialis 20mg® patients with severe liver failure must first assess the risk and benefit of Tadalafil Cialis 20mg.
In patients with diabetes mellitus during the use of Cialis Tadalafil Buy Online AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.
Tadalafil Citrate Dosage
