Recommendations and contraindications

Be sure to consult your doctor before taking Tadalafil Dosage For Erectile Dysfunction pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

• Like any other drug of this action, Tadalafil For Erectile Dysfunction is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
• The body, which is sensitive to any of the components of Buy Cialis Tadalafil, Buy Cialis Tadalafil is strictly contraindicated.
• It should not be used by persons under the age of 18.
• Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Tadalafil Generic Cialis 20mg.

Side effects and overdose

Due to the well-studied experience of Tadalafil Citrate Dosage, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

• Mild headaches
• Dizziness and vomiting
• A rush of blood to the face
• Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Dosage and administration

Inside. Use of Tadalafil Dosage For Erectile Dysfunction Cialis Tadalafil Tablets according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Tadalafil at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cheap Generic Tadalafil. The maximum daily dose of Tadalafil For Erectile Dysfunction is 20 mg. the Use of Cialis Tadalafil 20 Mg Tablets according to the indication of BPH or ED/BPH. The recommended dose of Cheap Generic Tadalafil when used once a day is 5 mg; Tadalafil Generic Cialis 20mg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil Cialis From India is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Tadalafil Citrate Dosage at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil Cialis From India in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil Usa practically displayed.

Interaction with other drugs

Buy Cialis Tadalafil is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil Usa. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Tadalafil Tablets reduced the rate of absorption of the latter without changing the AUC. Tadalafil Tablets Usp 20 Mg enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Tablets Usp 20 Mg on the metabolism of nitric oxide and cGMP. Therefore, the use of Tadalafil For Erectile Dysfunction in patients receiving nitrates is contraindicated

Pharmacological action

Tadalafil Usa for the treatment of erectile dysfunction. Tadalafil Cialis 20mg is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Tadalafil 5mg India leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Tadalafil Dosage For Erectile Dysfunction has no effect in the absence of sexual arousal.

In vitro studies have shown that Tadalafil Tablets India is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Tadalafil Usa on PDE5 is more active than on other PDES. Tadalafil 5mg India is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Tadalafil Canada is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis Tadalafil 20 Mg Tablets is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Tadalafil 10mg Tablets is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis Tadalafil Buy Online improves erection and increases the possibility of a full sexual intercourse.

Tadalafil Tablets Usp 20 Mg in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Tadalafil Cialis 20mg does not cause a significant change in heart rate. Buy Tadalafil Canada does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Tadalafil Eli Lilly on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Tadalafil 10mg Dosage on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Tadalafil Eli Lilly compared to placebo.

The efficacy and safety of Cialis Tadalafil 20 Mg Tablets (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Tadalafil 1 time/day. In studies of the primary efficacy of Buy Cialis Tadalafil at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Tadalafil Tablets Usp 20 Mg at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Mechanism of action

The active substance of Tadalafil Eli Lilly is Tadalafil 10mg Dosage, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil Generic Cialis 20mg.

Rules of admission

The duration of the generic Tadalafil Cialis 20mg reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil 5mg India should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

To sum up: buy Tadalafil Cialis From India (Cialis Tadalafil 10mg Tablets) should be because

• it has a duration of 36 hours.
• virtually no side effects
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