Pharmacokinetics
The pharmacokinetics of Cialis Tadalafil Buy Online in patients with erectile dysfunction is similar to the pharmacokinetics of Tadalafil Citrate Dosage in persons without erectile dysfunction. Absorption After taking Cheap Generic Tadalafil inside Tadalafil 40 Mg Dosage is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Tadalafil Tablets India does not depend on the meal, so Cialis Tadalafil Buy Online can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cheap Generic Tadalafil in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Tadalafil Usa 1 time/day. The average Vd is about 63 liters, which indicates that Tadalafil Cialis 20mg is distributed in the tissues of the body. The plasma protein binding of Tadalafil Citrate Dosage at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Tadalafil Cialis From India is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Tadalafil For Erectile Dysfunction. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Tadalafil Usa when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Tadalafil Cialis From India is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis Tadalafil Tablets when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Tadalafil 10mg Tablets (AUC), patients with severe renal insufficiency are not recommended to use Tadalafil 40 Mg Dosage. The pharmacokinetics of Tadalafil For Erectile Dysfunction in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Tadalafil Tablets to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Tadalafil 5mg India. In patients with diabetes mellitus during the use of Tadalafil Tablets Usp 20 Mg AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.
Dosage and administration
Inside. Use of Tadalafil Usa Tadalafil Cialis 20mg according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil Cialis 20mg at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Citrate Dosage. The maximum daily dose of Tadalafil Cialis From India is 20 mg. the Use of Tadalafil Tablets Usp 20 Mg according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil For Erectile Dysfunction when used once a day is 5 mg; Tadalafil Generic Cialis 20mg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil 40 Mg Dosage is contraindicated.
Side effect
Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.
Overdose
Symptoms: with a single appointment to healthy individuals Tadalafil 40 Mg Dosage at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil Usa in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil 10mg Dosage practically displayed.
Interaction with other drugs
Tadalafil Tablets India is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil 5mg India. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil 5mg India reduced the rate of absorption of the latter without changing the AUC. Tadalafil Generic Cialis 20mg enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Tadalafil Canada on the metabolism of nitric oxide and cGMP. Therefore, the use of Buy Tadalafil Canada in patients receiving nitrates is contraindicated
It is known that Tadalafil Usa increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Tablets Usp 20 Mg on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Tadalafil 10mg Dosage in patients receiving nitrates is contraindicated.
Buy Cialis Tadalafil does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Tadalafil Tablets Usp 20 Mg does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.
Buy Tadalafil Canada does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Tadalafil 10mg Dosage does not affect the action of warfarin against PV.
Tadalafil Citrate Dosage does not increase the duration of bleeding caused by acetylsalicylic acid.
Cialis Tadalafil 20 Mg Tablets has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.
In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Tadalafil For Erectile Dysfunction should be given appropriate clinical recommendations.
Did not observed a significant reduction in blood pressure in the application of Tadalafil Citrate Dosage in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.
Coadministration of Tadalafil 10mg Dosage with doxazosin is contraindicated. When using Tadalafil Tablets India healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.
Buy Tadalafil Canada did not affect the concentration of alcohol, nor did alcohol affect the concentration of Tadalafil 10mg Dosage. At high doses of alcohol (0.7 g/kg), Tadalafil Usa did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Tadalafil Tablets in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.
Tadalafil Tablets Usp 20 Mg has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.
Recommendations and contraindications
Be sure to consult your doctor before taking Tadalafil Cialis From India pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:
- Like any other drug of this action, Tadalafil Cialis From India is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
- The body, which is sensitive to any of the components of Tadalafil For Erectile Dysfunction, Cialis Tadalafil 10mg Tablets is strictly contraindicated.
- It should not be used by persons under the age of 18.
- Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Tadalafil Generic Cialis 20mg.
Side effects and overdose
Due to the well-studied experience of Cialis Tadalafil Buy Online, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:
- Mild headaches
- Dizziness and vomiting
- A rush of blood to the face
- Nasal congestion
When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.
Cialis Tadalafil Tablets
