Dosage and administration

Inside. Use of Tadalafil Citrate Dosage Cialis Tadalafil Buy Online according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil 40 Mg Dosage at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil Dosage For Erectile Dysfunction. The maximum daily dose of Cialis Tadalafil Tablets is 20 mg. the Use of Tadalafil 10mg Dosage according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil 40 Mg Dosage when used once a day is 5 mg; Tadalafil 10mg Dosage should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil Tablets Usp 20 Mg is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Tadalafil 20 Mg Tablets at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cheap Generic Tadalafil in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Tadalafil Buy Online practically displayed.

Interaction with other drugs

Cialis Tadalafil Tablets is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Tadalafil Cialis 20mg. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil 40 Mg Dosage reduced the rate of absorption of the latter without changing the AUC. Tadalafil 5mg India enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Tablets India on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Tadalafil 10mg Tablets in patients receiving nitrates is contraindicated

Pharmacokinetics

The pharmacokinetics of Tadalafil Generic Cialis 20mg in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Tadalafil Tablets in persons without erectile dysfunction. Absorption After taking Tadalafil Tablets Usp 20 Mg inside Tadalafil For Erectile Dysfunction is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Tadalafil Tablets India does not depend on the meal, so Tadalafil 40 Mg Dosage can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Tadalafil Cialis From India in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Tadalafil Citrate Dosage 1 time/day. The average Vd is about 63 liters, which indicates that Tadalafil Cialis From India is distributed in the tissues of the body. The plasma protein binding of Tadalafil Generic Cialis 20mg at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Tadalafil Cialis 20mg is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Tadalafil Dosage For Erectile Dysfunction. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Tadalafil Citrate Dosage when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Tadalafil Tablets India is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Tadalafil 10mg Dosage when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Tadalafil Cialis 20mg (AUC), patients with severe renal insufficiency are not recommended to use Tadalafil 10mg Dosage. The pharmacokinetics of Tadalafil Cialis 20mg in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Tadalafil Cialis 20mg to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cialis Tadalafil 20 Mg Tablets. In patients with diabetes mellitus during the use of Cialis Tadalafil 20 Mg Tablets AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Peculiar properties

On sale Tadalafil Dosage For Erectile Dysfunction first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Tadalafil Generic Cialis 20mg. As a result, the sale soon appeared exact copies of Cialis Tadalafil 20 Mg Tablets — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Tadalafil Dosage For Erectile Dysfunction, whether it will harm health — similar thoughts arise in many who want to buy Tadalafil 10mg Dosage. I must say that such doubts are in vain, as Tadalafil Cialis From India-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Tadalafil Eli Lilly is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis Tadalafil Tablets is based on the properties of Tadalafil Citrate Dosage, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

The long-term effect of Cheap Generic Tadalafil allows you not to worry about what you need to do everything in time: taking a pill, a man will be able to quality sexual intercourse within 1.5 days.

What else is the argument for purchasing Tadalafil Citrate Dosage?

Many men want to buy generic Cialis Tadalafil Tablets, not viagra, as in parallel with taking the pill you can drink alcohol and eat (even fat) without any health consequences. In addition, Tadalafil Dosage For Erectile Dysfunction does not serve as a reason for excitement, but only normalizes erectile function, allowing men to lead a full sexual life.

In addition, clinical trials have shown that men who underwent therapeutic treatment with Cialis Tadalafil 10mg Tablets, noticed an improvement in erection and after taking generic.

Mechanism of action

The active substance of Tadalafil Dosage For Erectile Dysfunction is Tadalafil 40 Mg Dosage, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil Tablets India.

Rules of admission

The duration of the generic Cialis Tadalafil 10mg Tablets reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil 40 Mg Dosage should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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