Peculiar properties
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The effect on the body Cheap Generic Tadalafil is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis Tadalafil Tablets is based on the properties of Cialis Tadalafil 20 Mg Tablets, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).
The long-term effect of Tadalafil 40 Mg Dosage allows you not to worry about what you need to do everything in time: taking a pill, a man will be able to quality sexual intercourse within 1.5 days.
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In addition, clinical trials have shown that men who underwent therapeutic treatment with Tadalafil Generic Cialis 20mg, noticed an improvement in erection and after taking generic.
Dosage and administration
Inside. Use of Cialis Tadalafil 10mg Tablets Tadalafil 40 Mg Dosage according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Tadalafil 10mg Dosage at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Tadalafil 10mg Dosage. The maximum daily dose of Tadalafil Citrate Dosage is 20 mg. the Use of Tadalafil Generic Cialis 20mg according to the indication of BPH or ED/BPH. The recommended dose of Tadalafil Generic Cialis 20mg when used once a day is 5 mg; Tadalafil Generic Cialis 20mg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Tadalafil Eli Lilly is contraindicated.
Side effect
Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.
Overdose
Symptoms: with a single appointment to healthy individuals Tadalafil 40 Mg Dosage at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Tadalafil 5mg India in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Tadalafil For Erectile Dysfunction practically displayed.
Interaction with other drugs
Cialis Tadalafil 20 Mg Tablets is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Tadalafil 10mg Tablets. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Tadalafil 40 Mg Dosage reduced the rate of absorption of the latter without changing the AUC. Tadalafil Dosage For Erectile Dysfunction enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tadalafil Buy Online on the metabolism of nitric oxide and cGMP. Therefore, the use of Buy Tadalafil Canada in patients receiving nitrates is contraindicated
Mechanism of action
The active substance of Tadalafil Dosage For Erectile Dysfunction is Cialis Tadalafil 10mg Tablets, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.
After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.
The highest concentration of the substance in the blood occurs approximately 2 hours after taking Tadalafil 5mg India.
Rules of admission
The duration of the generic Cialis Tadalafil 10mg Tablets reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Tadalafil Dosage For Erectile Dysfunction should be water.
Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.
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It is known that Tadalafil Eli Lilly increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Tadalafil Tablets Usp 20 Mg on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Tadalafil For Erectile Dysfunction in patients receiving nitrates is contraindicated.
Tadalafil Cialis From India does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Tadalafil 10mg Dosage does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.
Tadalafil Cialis From India does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Tadalafil 5mg India does not affect the action of warfarin against PV.
Tadalafil For Erectile Dysfunction does not increase the duration of bleeding caused by acetylsalicylic acid.
Tadalafil Tablets India has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.
In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Tadalafil 5mg India should be given appropriate clinical recommendations.
Did not observed a significant reduction in blood pressure in the application of Tadalafil Citrate Dosage in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.
Coadministration of Tadalafil Usa with doxazosin is contraindicated. When using Tadalafil Tablets India healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.
Cialis Tadalafil 10mg Tablets did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Tadalafil 20 Mg Tablets. At high doses of alcohol (0.7 g/kg), Tadalafil Tablets Usp 20 Mg did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Tadalafil Cialis 20mg in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.
Tadalafil Dosage For Erectile Dysfunction has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.
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